Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced...
Background: Although recent studies described important roles for carbonic anhydrase (CA) XII in epithelial carcinogenesis and tumor behavior, a consensus has not yet been reached regarding its...
View ArticleTranscriptomic and Functional Pathway Analysis of Human Cervical Carcinoma...
Background: There clearly is a need for effective chemotherapy for early-stage, high-risk patients with human cervical carcinoma. Vinblastine (VBL) is a key microtubule inhibitor, but unproven in its...
View ArticleRole of Chemokines in Non-Small Cell Lung Cancer: Angiogenesis and Inflammation
Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an...
View ArticleLoss of IRF8 Inhibits the Growth of Diffuse Large B-cell Lymphoma
IRF8 is a transcription factor with a critical role in B lymphocyte development and functions. Its role in human diffuse large B-cell lymphoma (DLBCL), however, remained elusive. In this study, using...
View ArticleInterleukin 37 Expression Inhibits STAT3 to Suppress the Proliferation and...
Objectives: The most recently discovered cytokine interleukin 37 (IL-37) received growing attention. Its function on tumor is largely unknown. Here, we investigated the biological function of IL-37 on...
View ArticlePrognostic Impact of ABO Blood Group on the Survival in Patients with Ovarian...
Purpose: The impact of ABO blood group on the survival of patients with ovarian cancer remains uncertain. The aim of this study was to evaluate the prognostic value of the ABO blood group in ovarian...
View ArticleBioimpedance Detection of Oral Lichen Planus Used as Preneoplastic Model
Introduction: Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It...
View ArticleMutation Analysis of Nine Chordoma Specimens by Targeted Next-Generation...
Background: Chordoma is a rare primary malignant bone tumour. Treatment options are mainly restricted to surgical excision, since chordomas are largely resistant to conventional ionising radiation and...
View ArticleIncreased Expression of Eps15 Homology Domain 1 is Associated with Poor...
One of the great challenges of small cell lung cancer (SCLC) treatment is identifying patients at high risk for recurrence after surgical resection and chemotherapy. We examined Eps15 homology domain...
View ArticleThe Histone Deacetylase Inhibitor Vaproic Acid Induces Cell Growth Arrest in...
Hepatocellular carcinoma (HCC) is a type of malignant cancer. Notch signaling is aberrantly expressed in HCC tissues with more evidence showing that this signaling plays a critical role in HCCs. In...
View ArticleAkt and Hippo Pathways in Ewing's Sarcoma Tumors and Their Prognostic...
Background: Ewing's sarcoma tumor is an aggressive malignancy of bone and soft tissue in children and young adults. Despite advances in modern therapy, metastasis occurs and results in high mortality....
View ArticleSolanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated...
Solanum incanum extract (SR-T100), containing the active ingredient solamargine, can induce apoptosis via upregulation of tumor necrosis factor receptor expression and activation of the mitochondrial...
View ArticleThe Regulation of Matrix Metalloproteinase Expression and the Role of...
Discoidin Domain Receptors (DDR1/DDR2) are tyrosine kinase receptors which are activated by collagen. DDR signalling regulates cell migration, proliferation, apoptosis and matrix metalloproteinase...
View ArticleThe Expression and Function of NUMB in Endometrial Cancer and the Interaction...
Background: Since more and more evidences support that NUMB orchestrates many cell physiological and pathological processes of diseases including cancer, based on our previous work, we studied deeply...
View ArticleA Muti-center, Randomized Phase II Study of Oxaliplatin and S-1 versus...
Background: Capecitabine plus oxaliplatin (XELOX) is considered one of the primary chemotherapy regimens for patients with metastatic colorectal cancer (CRC). Oxaliplatin plus S-1 (OS) has also...
View ArticleStaurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells...
Malignant tumors recur after chemotherapy. A small population of cancer stem-like cells within tumors is now generally considered the prime source of the recurrence. To better understand how cancer...
View ArticleWeaknesses and Pitfalls of Using Mice and Rats in Cancer Chemoprevention Studies
Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of...
View ArticleNucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during...
The subcellular localization, expression level, and activity of anti-cancer proteins alter in response to intrinsic and extrinsic cellular stresses to reverse tumor progression. The purpose of this...
View ArticleABC-Transporter Expression Does Not Correlate with Response to Irinotecan in...
Background: Active efflux of irinotecan by ATP-binding cassette (ABC)-transporters, in particular ABCB1 and ABCG2, is a well-established drug resistance mechanism in vitro and in pre-clinical mouse...
View ArticleParity Correlates with the Timing of Developing Endometrial Cancer, But Not...
Parity is one of well-known risk factors of endometrial cancer, but it is less clear whether parity is associated with the timing of developing endometrial cancer, and with the incidence of subtype of...
View ArticleReceptor for Hyaluronic Acid-Mediated Motility is Associated with Poor...
Receptor for hyaluronic acid (HA)-mediated motility (RHAMM) is a nonintegral cell surface receptor involved in the aggressive phenotype in a wide spectrum of human malignancies, but the significance...
View ArticleStereotactic Body Radiotherapy (SBRT) for Intrahepatic and Hilar...
Background: Unresectable intrahepatic and hilar cholangiocarcinomas carry a dismal prognosis. Systemic chemotherapy and conventional external beam radiation and brachytherapy have been used with...
View ArticlePotential Approaches and Recent Advances in Biomarker Discovery in Clear-Cell...
The early diagnosis and monitoring of clear-cell Renal Cell Carcinoma (ccRCC), which is the most common renal malignancy, remains challenging. The late diagnosis and lack of tools that can be used to...
View ArticleCDKN2 Gene Deletion as Poor Prognosis Predictor Involved in the Progression...
Deletion of cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) is well known in many hematologic malignancies, but only few reports have investigated this deletion effect on clinical prognosis. This...
View ArticleChemotherapeutic Response and Prognosis among Lung Cancer Patients with and...
Purpose: The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48)...
View ArticleHigh Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to...
Background: Pyruvate kinase M2 (PKM2) is the key enzyme in the Warburg effect, and it was recently reported to be involved in the metabolic pathways of chemotherapeutic drugs. However, the role of...
View ArticleRisk of Cancer in Patients with Insomnia, Parasomnia, and Obstructive Sleep...
Purpose: Insomnia, parasomnia, and obstructive sleep apnea have been associated with a number of disease pathologies, but little is known about the relationship of these sleep disorders and cancer....
View ArticleSecond-Line Therapy of Small-Cell Lung Cancer: Topotecan Compared to a...
Background: Randomized trials established topotecan and the combination of adriamycin, cyclophosphamide and vincristine (ACO) as second-line therapy options for small-cell lung cancer. We...
View ArticleCD20 Over-Expression in Hodgkin-Reed-Sternberg Cells of Classical Hodgkin...
We have scrutinized a previously analyzed cohort of classical Hodgkin lymphoma patients for evidence of a CD20 over-expression. This was pursued in order to determine whether all the 24 (12.6%)...
View ArticleIdentification and Validation of a Five MicroRNA Signature Predictive of...
Background: MicroRNA (miRNA) have been shown to be important in regulating gene expression in prostate cancer. We used next generation miRNA sequencing to conduct a whole miRNome analysis to identify...
View ArticleAnalysis of Clinical and Dosimetric Factors Influencing Radiation-Induced...
Purpose: Dose escalation of thoracic radiation can improve the local tumor control and surivival, and is in the meantime limited by the occurrence of radiation-induced lung injury (RILI). This study...
View ArticlePredicting the Response of Neoadjuvant Therapy for Patients with Esophageal...
Currently, the most promising strategy to improve the prognosis of advanced esophageal cancer is neoadjuvant chemoradiation (CRT) followed by surgery. However, patients who achieved pathological...
View ArticleSilencing of Survivin Expression Leads to Reduced Proliferation and Cell...
Survivin is an anti-apoptotic gene that is overexpressed in most human tumors. RNA interference using short interfering RNA (siRNA) can be used to specifically inhibit survivin expression. Tumor cells...
View ArticleVertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK...
Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic...
View ArticleMay Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?
Gastric cancer (GC) is the third leading cause of cancer-related deaths. More than 80% of the diagnosis was made at the advanced stages of the disease, highlighting the urgent demand for novel...
View ArticleExpression Profiling Identifies Bezafibrate as Potential Therapeutic Drug for...
Drug-induced gene expression patterns that invert disease profiles have recently been illustrated to be a new strategy for drug-repositioning. In the present study, we validated this approach and...
View ArticleThe Expression of CD9 and PIK3CD is Associated with Prognosis of Follicular...
Background: Follicular lymphoma (FL) frequently develops drug-resistance and transforms into more aggressive subtypes over time. It is urgent to find prognostic biomarkers and disclose signaling...
View ArticleMicroRNA-222 Controls Human Pancreatic Cancer Cell Line Capan-2 Proliferation...
Pancreatic cancer (PC) is one of the most common cancers and has a poor prognosis due to late diagnosis and ineffective therapeutic multimodality. MicroRNAs (miRNAs, miRs) are a group of non-coding,...
View ArticleA Fraction of CD133+ CNE2 Cells Is Made of Giant Cancer Cells with...
CD133 has been suggested as a broad-spectrum marker for cancer stem cells(CSCs). The present study investigated the expression of CD133 in biopsy tissues of nasopharyngeal carcinoma (NPC), NPC cell...
View ArticleHigh Expression of FGFR4 Enhances Tumor Growth and Metastasis in...
Background: FGF receptor (FGFR) family can be activated by FGFs and play important roles in regulating cell growth, differentiation, migration and angiogenesis. Recent studies suggested that FGFR4...
View ArticleCT120A Acts as an Oncogene in Head and Neck Squamous Cell Carcinoma
Squamous cell carcinoma of the head and neck (HNSCC) is among the most frequent cancers worldwide. The etiology and pathogenesis of HNSCC are influenced by multiple genetic factors in addition to...
View ArticleHsa-miR-301a-3p Acts as an Oncogene in Laryngeal Squamous Cell Carcinoma via...
Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant head and neck squamous cell carcinoma. Exploring the molecular indicators of malignant behavior will enhance our knowledge...
View ArticleSerum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for...
Background: Serum free fatty acids (FFAs) are correlated with pathological status, and change in serum FFA levels may be associated with thyroid diseases.Materials and Methods: In this study, 664...
View ArticleA Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug...
Chemotherapy based on hematogenous administration of drugs to lymph nodes (LNs) located outside the surgically resected area shows limited tissue selectivity and inadequate response rates, resulting...
View ArticleMiR-182 Is Associated with Growth, Migration and Invasion in Prostate Cancer...
Background: MicroRNA (miRNA) have been shown to regulate gene expression in many cancers. MiR-182 has recently been found to be prognostic for patients treated with radical prostatectomy for prostate...
View ArticleComprehensive Two- and Three-Dimensional RNAi Screening Identifies PI3K...
Triple-negative breast cancer (TNBC) is a major cause of death among breast cancer patients that results from intrinsic and acquired resistance to systemic chemotherapies. To identify novel targets...
View ArticlePLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived...
Over expression of various immunogenic melanoma associated antigens (MAAs) has been exploited in the development of immunotherapeutic melanoma vaccines. Expression of MAAs such as MART-1 and gp100 is...
View ArticleLow Dose, Low Cost Estradiol Pellets Can Support MCF-7 Tumour Growth in Nude...
MCF-7 cells are a slow growing estrogen receptor (ER) positive human breast cancer cell line that is commonly used to model estrogen responsive breast cancer cell growth in-vitro and tumour growth...
View ArticleKnockdown of hTERT and Treatment with BIBR1532 Inhibit Cell Proliferation and...
Telomerase activity and expression of the catalytic protein hTERT are associated with cell proliferation and advanced stage in endometrial cancer. Our objective was to evaluate the effect of...
View ArticleIdentification of Regulatory-RNAs for Alternative Splicing of Ron Proto-Oncogene
RON receptor tyrosine kinase is a proto-oncogene that induces cell migration and matrix invasion. RONĪ160 protein, which is produced by exclusion of exon 5 and 6, promotes cell migration, matrix...
View Article